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Date of publication: 27 December 2017


Team "Biotherapy" : Biotherapies by vectorization of nucleic acids

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2020 articles:

- E Savier, P Tuffery, H Bruzzoni-Giovanelli, A Rebollo. Tumor targeting as new therapeutic approach in liver cancer. Method Mol Biol, 2020, in press

- C Badaut, P Visitdesotrakul, A Chabry, P Bigey, P Tornyigah, J Roman, MJ Alao, A Annick, A Serge, G Sagbo, N Tuikue Ndam, AV Oleinikov, R Tahar. IgG acquisition against PfEMP1-DC 13 constructs, ICAM-1 binding DBLß and peptides of DBLß and DBLß domains in cerebral malaria children. Sci Rep, 2020 Dec, in press

- CZ Dong, P Tuffery, C Parizot, K Dorgham, JM Zini, H Bruzzoni-Giovanelli, A Rebollo. Identification of PP1/LRRK2 binding sites and design of interfering peptides with potential clinical application. PlosOne, 2020 Aug, 15(8) ; e0237110. doi.org/10.1371/journal.pone.0237110

- L Simon-Gracia, E Savier, C Parizot, JY Brossas, S Loisel, T Teesalu, F Conti, F Charllotte, O Scatton, L Aoudjehane, A Rebollo. Bifunctional therapeutic peptides for targeting malignant B cells and hepatocytes: proof of concept in chronic Lymphocytic leukemia. Advanced Therapeutic, 2020 Oct, 3(12). DOI:10.1002/adtp.202000131

- Reygner J, Charrueau C, Delannoy J, Mayeur C, Robert V, Cuinat C, Meylheuc T, Mauras A, Augustin J, Nicolis I, Modoux M, Joly F, Waligora-Dupriet AJ, Thomas M, Kapel N. Freeze-dried fecal samples are biologically active after long-lasting storage and suited to fecal microbiota transplantation in a preclinical murine model of Clostridioides difficile infection. Gut Microbes. 2020 Sep 2;11(5):1405-1422. doi: 10.1080/19490976.2020.1759489.

- Pastor M, Quiviger M, Pailloux J, Scherman D, Marie C. Reduced Heterochromatin Formation on the pFAR4 Miniplasmid Allows Sustained Transgene Expression in the Mouse Liver. Mol Ther Nucleic Acids. 2020 Sep 4;21:28-36. doi: 10.1016/j.omtn.2020.05.014.

- Domingues A, Boisson-Vidal C, Marquet de Rouge P, Dizier B, Sadoine J, Mignon V, Vessières E, Henrion D, Escriou V, Bigey P, Chaussain C, Smadja DM, Nivet-Antoine V. Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation. Angiogenesis. 2020 May;23(2):249-264. doi: 10.1007/s10456-019-09704-x.

- Maruelli S, Besio R, Rousseau J, Garibaldi N, Amiaud J, Brulin B, Layrolle P, Escriou V, Rossi A, Trichet V, Forlino A. Osteoblasts mineralization and collagen matrix is conserved upon specific Col1a2 silencing. Matrix Biology Plus. 2020 May;6–7: 100028. doi: 10.1016/j.mbplus.2020.100028

- Busignies V, Arruda DC, Charrueau C, Ribeiro MCS, Lachagès AM, Malachias A, Finet S, Rehman AU, Bigey P, Tchoreloff P, Escriou V. Compression of Vectors for Small Interfering RNAs Delivery: Toward Oral Administration of siRNA Lipoplexes in Tablet Forms. Mol Pharm. 2020 Apr 6;17(4):1159-1169. doi: 10.1021/acs.molpharmaceut

- Michel-Todó L, Bigey P, Reche PA, Pinazo MJ, Gascón J, Alonso-Padilla J. Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods. Vaccines (Basel). 2020 Mar 16;8(1):130. doi: 10.3390/vaccines8010130.

- Hoffmann C, Djerir NEH, Danckaert A, Fernandes J, Roux P, Charrueau C, Lachagès AM, Charlotte F, Brocheriou I, Clément K, Aron-Wisnewsky J, Foufelle F, Ratziu V, Hainque B, Bonnefont-Rousselot D, Bigey P, Escriou V. Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis. Sci Rep. 2020 Mar 2;10(1):3850. doi: 10.1038/s41598-020-60615-0.

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2019 articles:

- Michel-Todó L, Reche PA, Bigey P, Pinazo MJ, Gascón J, Alonso-Padilla J. In silico Design of an Epitope-Based Vaccine Ensemble for Chagas Disease. Front Immunol. 2019 Nov 22;10:2698. doi: 10.3389/fimmu.2019.02698.

- Hernandez M, Recalde S, Garcia-Garcia L, Bezunartea J, Miskey C, Johnen S, Diarra S, Sebe A, Rodriguez-Madoz JR, Pouillot S, Marie C, Izsvák Z, Scherman D, Kropp M, Prosper F, Thumann G, Ivics Z, Garcia-Layana A, Fernandez-Robredo P. Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization. Mol Ther Methods Clin Dev. 2019 Nov 9;15:403-417. doi: 10.1016/j.omtm.2019.10.013

- Pinyon JL, von Jonquieres G, Crawford EN, Duxbury M, Al Abed A, Lovell NH, Klugmann M, Wise AK, Fallon JB, Shepherd RK, Birman CS, Lai W, McAlpine D, McMahon C, Carter PM, Enke YL, Patrick JF, Schilder AGM, Marie C, Scherman D, Housley GD. Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes. Hear Res. 2019 Sep;380:137-149. doi: 10.1016/j.heares.2019.06.002.

- Basu N, Ho TH, Guillon FX, Zhang YY, Bigey P, Navakanta B, Bedioui F, Lazerges M. Coupling Electrochemical Adsorption and Long-Range Electron Transfer: Label-Free DNA Mismatch Detection with Ultramicroelectrode (UME). Electroanalysis 2019 Jul; doi: 10.1002/elan.201900357

- Giannakopoulos A, Quiviger M, Stavrou E, Verras M, Marie C, Scherman D, Athanassiadou A. Efficient episomal gene transfer to human hepatic cells using the pFAR4-S/MAR vector. Mol Biol Rep. 2019 Jun;46(3):3203-3211. doi: 10.1007/s11033-019-04777-9.

- Arruda DC, Gonzalez IJ, Finet S, Cordova L, Trichet V, Andrade GF, Hoffmann C, Bigey P, de Almeida Macedo WA, Da Silva Cunha A Jr, Malachias de Souza A, Escriou V. Modifying internal organization and surface morphology of siRNA lipoplexes by sodium alginate addition for efficient siRNA delivery. J Colloid Interface Sci. 2019 Mar 22;540:342-353. doi: 10.1016/j.jcis.2019.01.043.

- Mignet N, Marie C, Delalande A, Manta S, Bureau MF, Renault G, Scherman D, Pichon C. Microbubbles for Nucleic Acid Delivery in Liver Using Mild Sonoporation. Methods Mol Biol. 2019 March;1943:377-387.

- Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells. Pharmaceutics. 2019 Jan 21;11(1):47. doi: 10.3390/pharmaceutics11010047.

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2018 articles:

- Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, Toupet K, Mausset-Bonnefont AL, Cren M, Robin M, Georgel P, Nehmar R, Taams L, Grün J, Grützkau A, Häupl T, Pers YM, Jorgensen C, Duroux-Richard I, Courties G, Apparailly F. Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis. Theranostics. 2018 Nov 13;8(21):5972-5985.

- Quiviger M, Giannakopoulos A, Verhenne S, Marie C, Stavrou EF, Vanhoorelbeke K, Izsvák Z, De Meyer SF, Athanassiadou A, Scherman D. Improved molecular platform for the gene therapy of rare diseases by liver protein secretion. Eur J Med Genet. 2018 Nov;61(11):723-728.

- Pizzuto M, Bigey P, Lachagès AM, Hoffmann C, Ruysschaert JM, Escriou V, Lonez C. Cationic lipids as one-component vaccine adjuvants: A promising alternative to alum. J Control Release. 2018 Oct 10;287:67-77.

- Nordor AV, Bellet D, Siwo GH. Cancer-malaria: hidden connections. Open Biol. 2018 Oct 31;8(10).

- Pastor M, Johnen S, Harmening N, Quiviger M, Pailloux J, Kropp M, Walter P, Ivics Z, Izsvák Z, Thumann G, Scherman D, Marie C. The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells. Mol Ther Nucleic Acids. 2018 Jun 1;11:57-67.

- Valero L, Alhareth K, Espinoza Romero J, Viricel W, Leblond J, Chissey A, Dhotel H, Roques C, Campiol Arruda D, Escriou V, Mignet N, Fournier T, Andrieux K. Liposomes as Gene Delivery Vectors for Human Placental Cells. Molecules. 2018 May 4;23(5).

- Le Clanche S, Cheminel T, Rannou F, Bonnefont-Rousselot D, Borderie D, Charrueau C. Use of Resveratrol Self-Emulsifying Systems in T/C28a2 Cell Line as Beneficial Effectors in Cellular Uptake and Protection Against Oxidative Stress-Mediated Death. Front Pharmacol. 2018 May 24;9:538.

- Gauthé M, Richard-Molard M, Rigault E, Buecher B, Mariani P, Bellet D, Cacheux W, Lièvre A. Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy. BMC Cancer. 2018 Apr 13;18(1):417.

- Waligora-Dupriet AJ, Lafleur S, Charrueau C, Choisy C, Cynober L, Butel MJ, Moinard C. Head-injury profoundly affects gut microbiota homeostasis: results of a pilot study. Nutrition. 2018 Janv;45:104-107.

- Kopf PG, Park SK, Herrnreiter A, Krause C, Roques BP, Campbell WB. Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries. Endocrinology. 2018 Jan 1;159(1):238-247.

- Bedarida T, Domingues A, Baron S, Ferreira C, Vibert F, Cottart CH, Paul JL, Escriou V, Bigey P, Gaussem P, Leguillier T, Nivet-Antoine V. Reduced endothelial thioredoxin-interacting protein protects arteries from damage induced by metabolic stress in vivo. FASEB J. 2018 Jun;32(6):3108-3118.

- Kopf PG, Park SK, Herrnreiter A, Krause C, Roques BP, Campbell WB. Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries. Endocrinology. 2018 Jan 1;159(1):238-247.

- Roques BP. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins. Handb Exp Pharmacol. 2018;247:53-70.

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2017 articles:

- Garcia-Garcia L, Recalde S, Hernandez M, Bezunartea J, Rodriguez-Madoz JR, Johnen S, Diarra S, Marie C, Izsvák Z, Ivics Z, Scherman D, Kropp M, Thumann G, Prosper F, Fernandez-Robredo P, Garcia-Layana A. Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery. Mol Ther Nucleic Acids. 2017 Dec 15;9:1-11.

- Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet N. Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound-mediated transgene expression in liver. J Control Release. 2017 Sep;262:170-181.

- Poras H, Patouret R, Leiris S, Ouimet T, Fournié-Zaluski MC, Roques BP. Substituted α-mercaptoketones, new types of specific neprilysin inhibitors. Bioorg Med Chem Lett. 2017 Aug;27(16):3883-3890.

- Ho TH, Guillon FX, Bigey P, Bedioui F, Lazerges M. Analysis of the evolution of the detection limits of electrochemical nucleic acid biosensors II. Anal Bioanal Chem. 2017 Jul;409(18):4335-4352.

- Carillion A, Feldman S, Na N, Biais M, Carpentier W, Birenbaum A, Cagnard N, Loyer X, Bonnefont-Rousselot D, Hatem S, Riou B, Amour J. Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy. PLoS One. 2017 Jul 20;12(7):e0180103.

- Nordor AV, Nehar-Belaid D, Richon S, Klatzmann D, Bellet D, Dangles-Marie V, Fournier T, Aryee MJ. The Early Pregnancy Placenta Foreshadows DNA Methylation Alterations of Solid Tumors. Epigenetics. 2017 Jul; 12(9):793-803.

- Jensen DD, Lieu TM, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Klein Herenbrink C, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Christie MJ, Porter CJH, Canals M, Bunnett NW. Neurokinin 1 Receptor Signaling in Endosomes Mediates Sustained Nociception and is Viable Therapeutic Target for Prolonged Pain Relief. Science Translational Med. 2017 May;9:1-15.

- Leborgne C, Alimi-Guez D, El Shafey N, van Wittenberghe L, Bigey P, Scherman D, Kichler A. The absorption enhancer sodium deoxycholate promotes high gene transfer in skeletal muscles. Int J Pharm. 2017 May;523(1):291-299.

- Mamadou G, Charrueau C, Dairou J, Limas-Nzouzi N, Eto B, Ponchel G. Increased intestinal permeation of resveratrol formulated into self-emulsifying drug delivery systems. Int J Pharm. 2017 Apr;521:150-155.

- Thumann G, Harmening N, Prat-Souteyrand C, Marie C, Pastor M, Sebe A, Miskey C, Hurst LD, Diarra S, Kropp M, Walter P, Scherman D, Ivics Z, Izsvák Z, Johnen S. Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids. Mol Ther Nucleic Acids. 2017 Mar;6:302-314.

- De Jong A, Carreira S, Na N, Carillion A, Jiang C, Beuvin M, Lacorte JM, Bonnefont-Rousselot D, Riou B, Coirault C. Diaphragmatic function is enhanced in fatty and diabetic fatty rats. PlosOne. 2017 Mar;12(3):e0174043.

- Pizzuto M, Gangloff M, Scherman D, Gay NJ, Escriou V, Ruysschaert JM, Lonez C. Toll-like receptor 2 promiscuity is responsible for the immunostimulatory activity of nucleic acid nanocarriers. J Control Release. 2017 Feb;247:182-193.

- Gonzalez-Rodriguez S, Poras H, Menendez L, Lastra A, Ouimet T, Fournie-Zaluski MC, Roques BP, Baamonde A. Synergistic combinations of the dual enkehalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain. Scandinavian J Pain 2017 Jan;14:25-38.


2016 articles:

- Charrueau C, Moinard C, Brinkmann S, Choisy C, Butel MJ, Bureau MF, Le Plénier S, Brignole-Baudouin F, Neveux N, Cynober L, De Bandt JP. Evaluation of a new concept of immune-enhancing diet in a model of head-injured rat with infectious complications. Clin Nutr. 2016 Dec;35:1291-1300. IF=4,5

- Bonnard E, Poras H, Fournié-Zaluski MC, Roques BP. Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain. Eur J Pharmacol. 2016 Oct;788:176-182. IF=2,7

- Pelissier A, Roulot A, Guéry B, Bonneau C, Bellet D, Rouzier R. Serum CA125 and HE4 levels as predictors for optimal interval surgery and platinum sensitivity after neoadjuvant platinum-based chemotherapy in patients with advanced epithelial ovarian cancer. J Ovarian Res. 2016 Sept;9:61-67. IF=2,5

- Pham MH, Auzeil N, Regazzetti A, Scherman D, Seguin J, Mignet N, Dauzonne D, Chabot GG. Metabolism of Flavone-8-acetic Acid in Mice. Anticancer Res. 2016 Aug;36(8):3889-3898. IF=1,9

- Nassi A, Guillon FX, Amar A, Hainque B, Amriche S, Maugé D, Markova E, Tsé C, Bigey P, Lazerges M, Bedioui F. Electrochemical DNA-biosensors based on long-range electron transfer: optimization of the amperometric detection in the femtomolar range using two-electrode setup and ultramicroelectrode. Electrochim Acta. 2016 Aug;209:269–277. IF=4,8

- Jeannot E, Becette V, Caampitelli M, Calméjane MA, Lappartient E, Ruff E, Saada S, Holmes A, Bellet D, Sastre-Garau X. Circulating human papillomavirus DNA detected using droplet digital PCR in the serum of patients diagnosed with early stage human papillomavirus-associated invasive carcinoma. J Pathol Clin Res. 2016 Jun;2(4):201-209.

- Pham MH, Dauzonne D, Chabot GG. Not flavone-8-acetic acid (FAA) but its murine metabolite 6-OH-FAA exhibits remarkable antivascular activities in vitro. Anticancer Drugs. 2016 Jun;27(5):398-406.

- Bandje K, Naissant B, Bigey P, Lohezic M, Vayssières M, Blaud M, Kermasson L, Lopez-Rubio JJ, Langsley G, Lavazec C, Deloron P, Merckx A. Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum. Malar J. 2016 Apr;15:248. IF=3,1

- El-Shafey N, Guesnon M, Simon F, Deprez E, Cosette J, Stockholm D, Scherman D, Bigey P, Kichler A. Inhibition of the myostatin/Smad signaling pathway by short decorin-derived peptides. Exp Cell Res. 2016 Feb;341(2):187-195. IF=3,4


2015 articles:

- Herman S, Fischer A, Presumey J, Hoffmann M, Koenders MI, Escriou V, Apparailly F, Steiner G. Inhibition of inflammation and bone erosion by RNA interference-mediated silencing of heterogeneous nuclear RNP A2/B1 in two experimental models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Sept;67:2536-2546. IF=9,0

- Córdova G, Rochard A, Riquelme-Guzmán C, Cofré C, Scherman D, Bigey P, Brandan E. SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor β. J Cell Biochem, 2015 Sept;116(9):1880-1887. IF=3,4

- Poras H, Bonnard E, Fournié-Zaluski MC, Roques BP. Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route. Eur J Med Chem. 2015 Sep;102:58-67.

- Marimani MD, Ely A, Buff MCR, Bernhardt S, Engels JW, Scherman D, Escriou V, Arbuthnot P. Inhibition of replication of hepatitis b virus in transgenic mice following administration of hepatotropic lipoplexes containing guanidinopropyl-modified siRNAs. J Control Release. 2015 Jul;209:198-206. IF=8,4

- Maubec E, Laouénan C, Deschamps L, Nguyen VT, Scheer-Senyarich I, Wackenheim-Jacobs AC, Steff M, Duhamel S, Tubiana S, Brahimi N, Leclerc-Mercier S, Crickx B, Perret C, Aractingi S, Escoubet B, Duval X, Arnaud P, Jaisser F, Mentré F, Farman N. Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin. J Invest Dermatol. 2015 Jul;135(7):1781-1789. IF=6,9

- Thumann G, Perdikomati-Dahmen M, Izsvak Z, et al, Group Author(s):TargetAMD Consortium. Transposon-Based, Targeted Ex Vivo Gene Therapy to Treat Age-Related Macular Degeneration (TargetAMD). Hum Gene Ther Clin Dev. 2015 Jun;26(2):97-100. IF=4,1

- Maestrelli F, Zerrouk N, Cirri M, Mura P. Comparative evaluation of polymeric and waxy microspheres for combined colon delivery of ascorbic acid and ketoprofen. Int J Pharm. 2015 May;485(1-2):365-373. IF=4,0

- Aldaz-Carroll L, Richon S, Dangles-Marie V, Cocquebert M, Fournier T, Troalen F, Stevens D, Guery B, Hersant AM, Guibourdenche J, Nordor A, Pecking A, Bellet D. Specific detection of type II human chorionic gonadotropin beta subunit produced by trophoblastic and neoplastic cells. Clin Chim Acta. 2015 Apr;444:92-100. IF=2,8

- Hamoudi M, Henry E, Zerrouk N, Scherman D, Arnaud P, Deprez E, Escriou V. Enhancement of siRNA lipid-based vector stability and siRNA integrity in human serum with addition of anionic polymer adjuvant. J Drug Deliv Sci Technol. 2015 Apr;26:1-9. IF=0,7

- Rosa F, Corvis Y, Lai-Kuen R, Charrueau C, Espeau P. Influence of particle size on the melting characteristics of organic compounds. J Therm Anal Calorim. 2015 Apr; 120:783-787. IF=1,8

- Mai LH, Chabot GG, Grellier P, Quentin L, Dumontet V, Poulain C, Espindola LS, Michel S, Vo HT, Deguin B, Grougnet R. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). Eur J Med Chem. 2015 Mar;93:93-100. IF=3,9

- Bonnard E, Poras H, Nadal X, Maldonado R, Fournié-Zaluski MC, Roques BP. Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain. Pharmacol Res Perspect. 2015 Mar;3(2):e00116.

- Cordova L, Trichet V, Escriou V, Rosset P, Amiaud J, Battaglia S, Charrier C, Berreur M, Brion R, Gouin F, Layrolle P, Passuti N, Heymann D. Inhibition of osteolysis and increase of bone formation after local administration of siRNA targeting RANK in a polyethylene particle-induced osteolysis model. Acta Biomater. 2015 Feb,13:150-158. IF=6,4

- Weiswald LB, Bellet D, Dangles-Marie V. Spherical cancer models in tumor biology. Neoplasia. 2015 Jan;17:1-15. IF=4,5


2014 articles:

- Quiviger M, Arfi A, Mansard D, Delacotte L, Pastor M, Scherman D, Marie C. High and prolonged sulfamidase secretion by the liver of MPS-IIIA mice following hydrodynamic tail vein delivery of antibiotic-free pFAR4 plasmid vector. Gene Ther. 2014 Dec;21(12):1001-1007. IF=3,2

- Mahindhoratep S, Bouda HA, El Shafey N, Scherman D, Kichler A, Pichon Ch, Midoux P, Mignet N, Bureau MF. NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer. Biochim Biophys Acta. 2014 Nov;1840(11):3257-63. IF=5,1

- To Thi Kim L, Escriou V, Griveau S, Girard A, Griscom L, Razan F, Bédioui F. Arrays of ultramicroelectrodes for the simultaneous detection of nitric oxides and peroxynitrite in biological systems. Acta Electrochim. 2014 Sept;140:33-36. IF=4,8

- Dady A, Havis E, Escriou V, Catala M, Duband JL. Junctional neurulation: A unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects. J Neurosci. 2014 Sept;34(39):13208-21. IF=6,3

- Poras H, Bonnard E, Dangé E, Fournié-Zaluski MC, Roques BP. New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment. J Med Chem. 2014 Jul;57(13):5748-5763.

- Lonez C, Bessodes M, Scherman D, Vandenbranden M, Escriou V, Ruysschaert JM. Cationic lipids activate Toll-like receptor 2 and NLRP3 Inflammasome pathways. Nanomedicine. 2014 May;10(4):775-782. IF=5,7

- Amri A, Le Clanche S, Thérond P, Bonnefont-Rousselot D, Borderie D, Lai-Kuen R, Chaumeil JC, Sfar S, Charrueau C. Resveratrol self-emulsifying system increases the uptake by endothelial cells and improves protection against oxidative stress-mediated death. Eur J Pharm Biopharm. 2014 Apr;86:418-426. IF= 4,0

- Lantero A, Tramullas M, Pílar-Cuellar F, Valdizán E, Santillán R, Roques BP, Hurlé MA. TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions. J Neurosci. 2014 Apr;34(15):5385-5395. IF=6,3

- Balavoine F, Azizi M, Bergerot D, De Mota N, Patouret R, Roques BP, Llorens-Cortes C. Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug. Clin Pharmacokinet. 2014 Apr;53(4):385-395. IF=4,8

- Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. J Neurosci. 2014 Jan;34(3):1057-1066. IF=6,3


2013 articles:

- Crauste-Manciet S, Larquet E, Khawand K, Bessodes M, Chabot GG, Brossard D, Mignet N. Lipidic spherulites: formulation optimisation by paired optical and cryoelectron microscopy. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):1088-1094. IF=4,0

- El Sanharawi M, Touchard E, Benard R. Bigey P, Escriou V, Mehanna C, Naud MC, Berdugo M, Jeanny JC, Behar-Cohen F. Long-term efficacy of ciliary muscle electrotransfer of three sFlt-1 variants in a rat model of laser-induced choroidal neovascularization. Gene Ther. 2013 Nov;20(11):1093-1103. IF=3,2

- Poras H, Duquesnoy S, Fournié-Zaluski MC, Ratinaud-Giraud C, Roques BP, Ouimet T. A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity. Anal Biochem. 2013 Oct;441(2):152-161.

- Présumey J, Courties G, Louis-Plence P, Escriou V, Scherman D, Pers YM, Pène J, Kyburz D, Gay S, Jorgensen C, Apparailly F. Nicotinamide phosphoribosyltransferase / visfatin expression by inflammatory monocytes mediates arthritis pathogenesis. Ann Rheum Dis. 2013 Oct;72(10):1717-1724. IF=12,4

- Burgain A, Rochard A, Trollet C, Mazuet C, Popoff MR, Escriou V, Scherman D, Bigey P. DNA electroporation in rabbits as a method for generation of high-titer neutralizing antiserum : examples of the Botulinum toxins types A, B and E. Hum Vaccin Immunother. 2013 Oct;9(10):2147-2156. IF=3,6

- Doritchamou J, Bigey P, Nielsen MA, Gnidehou S, Ezinmegnon S, Burgain A, Massougbodji A, Deloron P, Salanti A, Tuikue Ndam N. Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA. Vaccine. 2013 Sept;31(41):4516-4522. IF=3,4

- Champion L, Lerebours F, Cherel P, Edeline V, Giraudet AL, Wartski M, Bellet D, Alberini JL. 18F-FDG PET/CT imaging versus dynamic contrast-enhanced CT for staging and prognosis of inflammatory breast cancer. Eur J Nucl Med Mol Imaging. 2013 Aug;40:1206-1213. IF=5,5

- Nastasa C, Duma M, Marie C, Scherman D, Tiperciuc B, Oniga O. New N-Substituted 5-Chromenyl-Thiazolidinediones as Antimicrobial and Antiproliferative Agents. Digest J Nanomat Biostructures. 2013 Jul-Sept;8:1079-1087. IF=0,8

- Seguin J, Doan BT, Latorre Ossa H, Jugé L, Gennisson JL, Tanter M, Scherman D, Chabot GG, Mignet N. Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma. Int J Mol Imaging. 2013 Jul;2013:983534.

- Ouimet T, Duquesnoy S, Poras H, Fournié-Zaluski MC, Roques BP. Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity. J Biomol Screen. 2013 Jul;18(6):726-735.

- Moinard C, Delpierre E, Loï C, Neveux N, Butel MJ, Cynober L, Charrueau C. An oligomeric diet limits the response to injury in traumatic brain-injured rats. J Neurotrauma. 2013 Jun;30(11):975-980. IF=4,4

- Lazerges M, Tal VT, Bigey P, Scherman D, Bedioui F. Electrochemical DNA-biosensors: two-electrode setup well adapted for miniaturized devices. Sensors and Actuators B-Chemical. 2013 Jun;182:510-513. IF=4,8

- Fenard D, Genries S, Scherman D, Galy A, Martin S, Kichler A. Infectivity enhancement of different HIV-1-based lentiviral pseudotypes in presence of the cationic amphipathic peptide LAH4-L1. J Virol Methods. 2013 May;189(2):375-378. IF=1,5

- Ngo D, Beaulieu E, Gu R, Leaney A, Santos L, Fan H, Yang Y, Kao W, Xu J, Escriou V, Loiler S, Vervoordeldonk M, Morand EF. Divergent effects of endogenous and exogenous glucocorticoid-induced leucine zipper in animal models of inflammation and arthritis. Arthritis Rheum. 2013 May;65(5):1203-1212. IF=9,0

- Weiswald L-B, Richon S, Massonnet G, Guinebretière JM, Vacher S, Laurendeau I, Cottu P, Marangoni E, Nemati F, Validire P, Bellet D, Bieche I, Dangles-Marie V. A short-term colorectal cancer sphere culture as relevant tool for human cancer biology investigation. Br J Cancer. 2013 Apr;108:1720-1731. IF=5,6

- Ty N, Pontikis R, Chabot GG, Devillers E, Quentin L, Bourg S, Florent JC. Synthesis and biological evaluation of enantiomerically pure cyclopropyl analogues of combretastatin A4. Bioorg Med Chem. 2013 Mar;21(5):1357-1366. IF=3,0

- Elamari H, Slimi R, Chabot GG, Quentin L, Scherman D, Girard C. Synthesis and in vitro evaluation of potential anticancer activity of mono- and bis-1,2,3-triazole derivatives of bis-alkynes. Eur J Med Chem. 2013 Feb;60:360-364. IF=3,9

- Seguin J, Brullé L, Boyer R, Lu YM, Ramos Romano M, Touil YS, Scherman D, Bessodes M, Mignet N, Chabot GG. Liposomal encapsulation of the natural flavonoid fisetin improves bioavailability and antitumor efficacy. Int J Pharm. 2013 Feb;444(1-2):146-154. IF=4,0

- Schlegel A, Bigey P, Dhotel H, Scherman D, Escriou V. Reduced in vitro and in vivo toxicity of siRNA-lipoplexes with addition of Polyglutamate. J Control Release. 2013 Jan;165:1-8. IF=8,4


2012 articles:

- Schreiter A, Gore C, Labuz D, Fournie-Zaluski MC, Roques BP, Stein C, Machelska H. Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. FASEB J. 2012 Dec;26(12):5161-5171. IF=5,3

- Guiraud S, van Wittenberghe L, Georger C, Scherman D, Kichler A. Identification of decorin derived peptides with a zinc dependent anti-myostatin activity. Neuromuscul Disord. 2012 Dec;22(12):1057-1068. IF=3,1

- Doritchamou J, Bertin G, Moussiliou A, Bigey P, Viwami F, Ezinmegnon S, Fievet N, Massougbodji A, Deloron P, Tuikue Ndam N. First trimester Plasmodium falciparum infections display a typical ‘placental’ phenotype. J Inf Dis. 2012 Dec;206(12):1911-1919. IF=6,3

- Mur Blanch N, Chabot GG, Quentin L, Scherman D, Bourg S, Dauzonne D. In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4. Eur J Med Chem. 2012 Aug;54:22-32. IF=3,9

- Bordbar B, Gnidehou S, Tuikue Ndam N, Doritchamou J, Moussiliou A, Quiviger M, Deloron P, Scherman D, Bigey P. Electroporation-Mediated Genetic Vaccination for Antigen Mapping: Application to Plasmodium falciparum VAR2CSA Protein. Bioelectrochemistry. 2012 Oct;87:132-137. IF=3,6

- Marc Y, Gao J, Balavoine F, Michaud A, Roques BP, Llorens-Cortes C. Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats. Hypertension. 2012 Aug;60(2):411-418. IF=6,3

- Seguin J, Nicolazzi C, Mignet N, Scherman D, Chabot GG. Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours. Tumour Biol. 2012 Oct;33(5):1709-1717. IF=2,9

- Touchard E, Heiduschka P, Berdugo M, Kowalczuk L, Bigey P, Chahory S, Gandolphe C, Jeanny J-C, Behar-Cohen F. Non viral gene therapy for GDNF production in RCS rat: The crucial role of the plasmid dose. Gene Ther. 2012 Sept; 19(9):886-898. IF=3,2

- Maestrelli F, Cirri M, Mennini N, Bragagni M, Zerrouk N, Mura P. Influence of cross-linking agent type and chitosan content on the performance of pectinate-chitosan beads aimed for colon-specific drug delivery. Drug Dev Ind Pharm. 2012 Sep;38(9):1142-1151. IF=2,4

- Jugé L, Doan BT, Seguin J, Albuquerque M, Larrat B, Mignet N, Chabot GG, Scherman D, Paradis V, Vilgrain V, Van Beers BE, Sinkus R. Colon tumor growth and antivascular treatment in mice: complementary assessment with MR elastography and diffusion-weighted MR imaging. Radiology. 2012 Aug;264(2):436-444. IF=6,8

- Touchard E, Berdugo M, Bigey P, El Sanharawi M, Savoldelli M, Naud MC, Jeanny JC, Behar-Cohen F. Suprachoroidal Electrotransfer: A Nonviral Gene Delivery Method to Transfect the Choroid and the Retina Without Detaching the Retina. Mol Ther. 2012 Aug;20(8):1559-1570. IF=6,9

- Gerard X, Perrault I, Hanein S, Silva E, Bigot K, Defoort-Delhemmes S, Rio M, Munnich A, Scherman D, Kaplan J, Kichler A, Rozet JM. AON-mediated Exon Skipping Restores Ciliation in Fibroblasts Harboring the Common Leber Congenital Amaurosis CEP290 Mutation. Mol Ther Nucleic Acids. 2012 Jun;1:e29. IF=5,0

- Iacobucci V, Di Giuseppe F, Bui TT, Vermeer LS, Patel J, Scherman D, Kichler A, Drake AF, Mason AJ. Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer. Biochim Biophys Acta. 2012 May;1818(5):1332-1341. IF=5,1

- Ragelle H, Crauste-Manciet S, Seguin J, Brossard D, Scherman D, Arnaud P, Chabot GG. Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice. Int J Pharm. 2012 May;427(2):452-459. IF=4,0

- Noble F, Benturquia N, Crete D, Canestrelli C, Mas Nieto M, Wilson J, Roques BP. Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats. Addict Biol. 2012 May;17(3):528-538. IF=4,5

- Ouimet T, Lancelot E, Hyafil F, Rienzo M, Deux F, Lemaître M, Duquesnoy S, Garot J, Roques BP, Michel JB, Corot C, Ballet S. Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging. Mol Pharm. 2012 Apr;9(4):850-861. IF=4.3

- Mortazavi-Jehanno N, Giraudet AL, Champion L, Lerebours F, Le Stanc E, Edeline V, Madar O, Bellet D, Pecking AP, Alberini JL. Assessment of response to endocrine therapy using FDG PET/CT in metastatic breast cancer: a pilot study. Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):450-460. IF=5,5

- Elwafi F, Curis E, Zerrouk N, Neveux N, Chaumeil JC, Arnaud P, Cynober L, Moinard C. Endotoxemia affects citrulline, arginine and glutamine bioavailability. Eur J Clin Invest. 2012 Mar;42(3):282-289. IF=2,7

- Bordbar B, Tuikue Ndam N, Bigey P, Doritchamou J, Scherman D, Deloron P. Identification of Id1-DBL2X of VAR2CSA as a Key Domain Inducing Highly Inhibitory and Cross-Reactive Antibodies. Vaccine. 2012 Feb;30(7):1343-1348. IF=3,4

- Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D. Essential requirement for alpha-arrestin2 in mouse intestinal tumors with elevated Wnt Signalling. Proc Natl Acad Sci USA. 2012 Feb;109(8):3047-3052. IF=9,7

- Wintgens V, Leborgne C, Baconnais S, Burckbuchler V, Le Cam E, Scherman D, Kichler A, Amiel C. Smart DNA vectors based on cyclodextrin polymers: compaction and endosomal release. Pharm Res. 2012 Feb;29(2):384-396. IF=3,3

- Mignet N, Seguin J, Ramos Romano M, Brullé L, Touil YS, Scherman D, Bessodes M, Chabot GG. Development of a liposomal formulation of the natural flavonoid fisetin. Int J Pharm. 2012 Feb;423(1):69-76. IF=4,0

- Jutkiewicz EM, Roques BP. Endogenous opioids as physiological antidepressants: complementary role of δ receptors and dopamine. Neuropsychopharmacology. 2012 Jan;37(1):303-304. IF=6,4