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Research Themes
Date of publication: 26 January 2017
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Team "Vector" : Vectors for molecular imaging and targeted therapy
1. Pre-formulation and drug properties
- P. Espeau, Y. Corvis
- Characterization of polymorphs
- Study of interactions of surfactants, determination of phase diagrams, eutectic mixtures
- Thermal tools development for characterization of complex molecular nanosystems used for vectorization.
- R. Gahoual, P. Houzé
- Conception of analytical methods for the characterization of biotherapeutics and nanovectors
- Clinical transfer
2. Conception of Nanomedicine for therapeutic targeting and drug delivery
- K. Andrieux, V. Boudy, C. Roques, N. Mignet
- Design, synthesis and study of new molecular or particulate vectors, and their targeting
- Design, synthesis and study of new delivery systems of the sol- gels bioadhesive type
3. Nanoparticles for MRI, optical and ultrasound imaging
- C. Richard, H. Dhotel, N. Mignet
- Persistent luminescence nanoparticles , functionalization, targeting and validation
- Protein or non-protein nanoparticle systems for imaging of liver function
- Ultrasound contrast agents and microbubbles for gene delivery
- Mixed MRI and optical designed nanosystems
4. In vitro and in vivo evaluation of our Nanomedicine approaches
- J. Seguin
- in vitro evaluation of nanoparticle uptake
- Pharmacokinetic studies
- Optical imaging platform (LIOPA)
- Establishment of tumor and metastases models in mice liver: models CT26 , 3LL
- Monitoring of tumor growth and decay by imaging
- Optimization of imaging techniques for quantification and diagnosis